Duterine® is a proprietary extract from the Piper species. In vitro evidence indicates that it inhibits drug metabolizing enzymes (e.g. CYP1A1, CYP1B1, CYP1B2, CYP2E1, CYP3A4 et al), stimulates absorption by stimulating gut amino acid transporters, inhibits the cell pump responsible for drug elimination from cells and inhibits intestinal production of glucuronic acid. RNI is currently testing the pharmacokinetic effects of Duterine on various active natural substances in humans.
Pango™ (BDO05) is a proprietary extract from species Acmella standardized to an N-alkylamide content with antinociceptive properties. It also may exhibit beneficial applicability to increase local as well as systemic pharmacological effects of dermally co-administrated molecules.